초임계 이산화탄소 RESOLV 공정을 이용한 PAc-β-CD의 미립화
- Abstract
- 초임계 이산화탄소를 이용한 공정으로 퍼아세틸레이티드 사이클로덱스트린(peracetylated cyclodextrin (PAc CD))의 노즐 분사를 통하여 초미립자 크기 입자를 제조하였다. 초임계 유체에 용해된 물질을 급속 팽창함으로서 미립자를 만드는 통상적인 방법중인 RESOLV 방법은 가압된 초임계 용액을 계면활성제가 포함된 외부용액, 주로 물속으로 급속 팽창하는 방식이다. 고압 반응기 내부에 PAc-β-CD를 넣고 고압 실린지 펌프를 이용하여 가압한 후 45℃를 유지하며 교반기를 이용하여 교반시킨다. 얻어진 유체의 PAc-β-CD를 일정시간 뒤 50~150㎛ 구경의 모세관을 통하여 계면활성제가 포함된 수용액상으로 빠르게 방출하여 초미세 입자를 제조하였다. 초미세 입자의 크기를 SEM과 DLS를 사용하여 관찰한 결과 0.7~3.0㎛로 측정 되었다. 계면활성제의 변화, 압력의 변화, 모세관의 길이와 직경에 따른 다양한 실험조건에 대해서 입자 제조 결과를 조사하였고 omeprazole을 including시켜 drug delivery의 가능성을 확인 하였다.
- Issued Date
- 2015
- Awarded Date
- 2015. 2
- Type
- Dissertation
- Publisher
- 부경대학교
- Affiliation
- 부경대학교
- Department
- 대학원 이미지시스템공학과
- Advisor
- 임권택
- Table Of Contents
- 목차 ······························································································· ⅰ
List of Figures ·············································································· ⅲ
List of Tables ··············································································· ⅳ
Abstract ························································································ ⅴ
Ⅰ. 서 론 ························································································ 1
Ⅱ. 이론적 배경 ··············································································· 6
2.1 초임계 유체 ··········································································· 6
2.2 초임계 이산화탄소 ·································································· 6
2.3 초임계 결정화 ········································································ 9
2.3.1 RESS ················································································ 9
2.3.2 GAS ················································································· 11
2.3.3 PGSS ················································································ 11
2.3.4 RPSS ················································································ 12
2.4 RESOLV ················································································ 12
2.5 PAc-β-CD(peracylated-β-cyclodextrin)··································· 13
2.6 OMP(Omeprazole)··································································· 13
2.7 Drug Delivery········································································ 14
Ⅲ. 실 험 ························································································ 15
3.1 시 약 ···················································································· 15
3.2 실험장치 ················································································ 15
3.3 실험방법 ················································································ 17
3.4 분석방법 ················································································ 17
Ⅳ. 결 과 ························································································ 18
4.1 PAc-β-CD의 결정···································································· 18
4.2 모세관의 변화 ········································································ 23
4.2.1 모세관의 길이 ·································································· 23
4.2.2 모세관의 직경 ·································································· 26
4.3 압력의 변화 ··········································································· 29
4.4 계면활성제의 변화 ·································································· 31
4.5 Drug(omeprazole)··································································· 34
Ⅴ. 결 론 ························································································ 36
Ⅵ. 참고문헌 ·················································································· 37
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- Master
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