피부 병원균에 대한 톱니모자반 추출물의 항균효과

Abstract

Staphylococcus aureus, S. epidermidis, Pseudomonas aeruginosa, Propionibacterium acnes and Candida albicans have been known as common pathogens of human skin. These strains are often involved in the development of abnormal follicular keratinization and inflammation as known acne vulgaris (Lee et al., 2014). The currently available therapeutic option for these skin pathogens is usually antibiotic treatment to kill the microbes. However, the application of antibiotic treatment is often associated with several side effects, such as the emergence of antibiotic resistance, organ damage, and immune hypersensitivity, if these medicines are used for a long period. As shown in Fig. 1, S. aureus become serious problems due to the increase in vancomycin-resistant S. aureus (VRSA) and methicillin-resistant S. aureus (MRSA) (Lee et al., 2009). P. aeruginosa is also multiple drug resistance bacteria that has more than two tolerances (Yoo et al., 2008). Appearance of these resistant bacteria is fatal in the place like hospital, in which there are a lot of people with lack of immunity, since they can survive by the treatment of antimicrobial agent due to their drug resistance. For these reasons, it was necessary to investigate natural agents exhibiting considerable antimicrobial effect against pathogens of human skin without side effects. Recently, marine organisms have been the focus of much attention on the development of a bioactive agent possessing various biological activities such as antioxidant, anti-inflammatory and anti-cancer effect (Ahn et al., 2011; Gupta and Nissereen, 2011). However, there are not enough literatures on the antimicrobial activity of marine secondary metabolites against pathogens of human skin. Thus, the aim of this study was to conduct an investigation into the anti-pathogens of human skin effect of marine algae. Among of brown algae, it has been reported that there are 30 species of Sargassum sp. in Korea (Oak and Lee, 2006). Also, there are several reports on biological activities of of Sargassum sp. (Hwang et al., 2006; Joung et al., 2012; Kim et al., 2007; Ko et al., 2010). The studies were mostly focused on antioxidant, anti-inflamatory and anti-cancer. (Bae, 2004; Hwang et al., 2006; Joung et al., 2012; Kim et al., 2007; Ko et al., 2010). Therefore, this study demonstrates the antimicrobial activity of Sargassum sp. extracts against pathogens of human skin. The results obtained in this study will contribute to develop an alternative therapeutic approach for controlling pathogens of human skin.