Synthesis of stimuli-responsive drug delivery systems via RAFT polymerization and Diels-Alder click reaction for doxorubicin release
- Affiliation
- 부경대학교 대학원
- Department
- 대학원 융합디스플레이공학과
- Advisor
- 임권택
- Table Of Contents
- Chapter 1 1
1.1. Introduction to stimuli-responsive drug delivery system 1
1.1.1. pH response 1
1.1.2. Redox response 2
1.2. Reversible addition-fragmentation chain transfer (RAFT) polymerization 3
1.3. Diels-Alder click reaction 5
1.4. Aim and outline of the thesis 8
1.5. Reference 8
Chapter 2 12
2.1. Introduction 13
2.2. Experimental section 15
2.2.1. Materials 15
2.2.2. Synthesis of PEO-b-PFMA 16
2.2.3. Determination of the critical micelle concentration (CMC) and stability of PEO-b-PFMA micelle 17
2.2.4. DOX loading and CCL micelles of PEO-b-PFMA 17
2.2.5. In vitro drug release 18
2.2.6. Cell viability assay 18
2.2.7. Confocal laser scanning microscopy (CLSM) observation 18
2.2.8. Characterization 18
2.3. Results and discussion 19
2.3.1. Synthesis and characterization of CCL micelles 19
2.3.2. Stability and reactivity of non-CCL and CLL micelles 24
2.3.3. Drug loading 25
2.3.4. In vitro release 25
2.3.5. Cytotoxicity of blank micelles and DOX-loaded micelles 26
2.4. Conclusions 30
2.5. References 30
Chapter 3 34
3.1. Introduction 35
3.2. Experimental section 36
3.2.1. Materials 36
3.2.2. Synthesis of furfuryl bearing RAFT agent (FA-DDMAT) 36
3.2.3. Anchoring RAFT agent on MWNTs 37
3.2.4. Preparation of poly(styrene-alt-maleic anhydride) grafted MWNTs (MWNT/PSMA) by surface initiated ‘‘grafting from’’ polymerization 37
3.2.5. Preparation of MWNT/PSMA-DOX 37
3.2.6. DOX release from MWNT/PSMA-DOX 38
3.2.7. Characterization 38
3.3. Results and discussion 39
3.3.1. Synthesis and characterization 39
3.3.2. In vitro release 43
3.4. Conclusion 44
3.5. References 44
- Degree
- Master
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