노닐페놀(NP) 노출에 따른 감성돔, Acanthopagrus schlegeli의 생리, 생화학적 반응

Abstract

Endocrine disruptors (EDs) imitate natural hormones in the endocrine system causing harmful effects on human and wildlife (Maguire 1999). Nonylphenol (NP) is one of the type of EDs. It has the ability to combinate human estrogen receptors, causing disruption in hormonal regulatory system (Ning et al. 2007). Also, causing a variety of hematologic effects, oxidative stress, physiological effect and immunological changes. Toxic effects of NP were reported in fish, observed invertebrates and mammals (Staples et al. 2004). The objective of this study was observed to biochemical, immunological and physiological response exposed to nonylphenol (0, 80, 160, 320 ㎍/L) in black seabream, Acanthopagrus schlegeli (mean length 16.71 ± 0.9 cm, mean weight 80.15 ± 13 g) during 4weeks. Hematoiogical factors, red blood cell count, white blood cell count and hematocrit levels showed a tendency to decrease with increasing concentration of nonylphenol. Calcium and magnesium in the plasma was increased significantly. Total protein was increased and glucose showed no significant change. GOT was decreased and GPT showed significant increased. Antioxidant enzymes factors, SOD, CAT, GSH, GST showed a tendency to increase with increasing concentration of nonylphenol. Stress Indicators factors, cortisol was decreased at 2weeks, 80 ㎍/L but increased at 4weeks, 80 ㎍/L. AchE was decreased at 2, 4weeks. Immunological factors, lysozyme was increased at 2weeks, but decreased in high concentration of nonylphenol at 4weeks. NP affect hematology and immune system. So NP harms metabolism and physiology of black sea bream.