다기능성 단일나노뉴브를 이용한 표적화 된 유방암의 광열치료 연구

Abstract

Recently, photothermal therapy (PTT) technique is greatly considered in cancer therapy owing to its unique advantages of specificity. Among a range of materials have been applied in photothermal therapy, single-walled carbon nanotubes (SWNTs) are considered to be an efficient material owing to their unique properties such as strong optical light absorption of near-infrared (NIR) light and efficient conversion of light to heat. Further, the combined photo-thermal therapy with chemotherapy is an effective approach in cancer treatment. In this way, we propose the modification of SWNTs with anticancer drug Doxorubicin (DOX) loading and anti-HER-2 antibody Herceptin conjugation to target breast cancer. The modified-SWNTs with DOX and Herceptin were utilized for PTT therapy under 808 nm NIR laser irradiation onto the HER-2-positive SK-BR-3 breast cancer cells. The anticancer drug, DOX and Herceptin conjugated SWNTs exhibited an excellent anticancer therapeutic efficiency via HER-2-receptor mediated enhanced-endocytosis and NIR-promoted chemo/photothermal damage following NIR light irradiation. These results suggest that the combination of the targeted chemo/photothermal therapy might result in the effective photothermal ablation of tumor cells.

Keywords: photothermal therapy, single-walled carbon nanotubes, Herceptin, NIR laser irradiation, endocytosis