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Alternative Title: MRI signal and Luminescence properties of Gd2O3:Pr3+ nano spheres as bifunctional contrast agents by co-precipitation method

Abstract: Praseodymium doped gadolinium oxide material is useful material in optical device, contrast agent and biomedicine due to their paramagnetic, strong red emission and chemical stability. Therefore, it can be applied to the both magnetic resonance imaging (MRI) and X-ray computed tomography (CT) as contrast agent and optical devices. In this research, red emitting Gd2O3:Pr3+ nano sphere phosphors were successfully fabricated by using the facile co-precipitation method with adjusting the reaction time from 1 to 4 h. The change of reaction time influences the morphology and size of Gd2O3:Pr3+ was analyzed. The XRD patterns of Gd2O3:Pr3+ appeared the cubic structure. The samples are exhibited the homogeneous Gd2O3:Pr3+ spheres with different sizes from 110 to 250 nm through the FE-SEM images. It affects the luminescence intensity and MR imaging signal intensity. Therefore, it can be selectively applied for bi-functional contrast agents prepared by simple process.

URI: https://repository.pknu.ac.kr:8443/handle/2021.oak/14606
http://pknu.dcollection.net/common/orgView/200000115422

Table Of Contents: 목 차
Abstract vii
1. 서론 1
2. 배경이론 3
2.1 MRI 3
2.1.1 초전도자석 4
2.1.2 외부 자장에서의 수소원자핵 5
2.1.3 이완 과정 8
2.1.4 MRI 조영제 13
2.1.5 MRI 조영제 작용기전 14
2.2 형광체 16
2.2.1 형광체 구성요소 16
2.2.2 형광 메커니즘 18
2.3 Pr3+의 형광특성 20
3. 실험방법 22
3.1 공침법 22
3.2 Gd2O3:Pr3+ 형광조영제의 합성 25
3.3 물성 측정 26
3.3.1 TG-DTA 측정 26
3.3.2 XRD 측정 28
3.3.3 XPS 측정 30
3.3.4 FT-IR 측정 31
3.3.5 Raman 측정 32
3.3.6 FE-SEM 측정 33
3.3.7 FE-TEM 측정 35
3.3.8 Time Resolved Spectrometer 측정 37
3.3.9 MRI 측정 38
4. 실험결과 및 고찰 39
4.1 열적분석 39
4.1.1 Gd2O3:Pr3+ 형광조영제의 TG-DTA 분석 39
4.2 구조분석 41
4.2.1 Gd2O3:Pr3+ 형광조영제의 XRD 패턴 분석 41
4.2.2 Gd2O3:Pr3+ 형광조영제의 XPS 스펙트럼 분석 42
4.2.3 Gd2O3:Pr3+ 형광조영제의 FT-IR 스펙트럼 분석 44
4.2.4 Gd2O3:Pr3+ 형광조영제의 Raman 스펙트럼 분석 45
4.3 표면분석 46
4.3.1 Gd2O3:Pr3+ 형광조영제의 SEM/TEM 이미지 46
4.3.2 Gd2O3:Pr3+ 형광조영제의 EDX 스펙트럼 분석 49
4.4 형광분석 50
4.4.1 Gd2O3:Pr3+ 형광조영제의 PLE, PL 스펙트럼 분석 50
4.5 MRI 신호강도분석 53
4.5.1 Gd2O3:Pr3+ 형광조영제의 MRI 신호강도 분석 53
5. 결론 55
참고문헌 56

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