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PUKYONG Repository 대학원 공업화학과

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Abstract: Photothermal therapy, which treats cancer through apoptosis by hyperthermia, requires stable, heat-conversion-efficient photothermal materials. Here we report an engineered nanoparticle consist of a highly photostable quarterrylene organic near-infrared (NIR) dye, IR788, encapsulated in polymeric micelles for generating heat under NIR irradiation. In addition, the core of micelle is stabilized via semi-interpenetrating network formation (sIPN), which ensures stable loading under low temperature. The resulting system showed a better photothermal characteristics compared to Indocyanine Green, a popular NIR absorber.
고온에 의한 세포사멸을 통해 암을 치료하는 광열치료법은 안정하고 열전환 효율이 높은 광열물질을 필요로한다. 이 논문에서는 근적외선 조사 하에서 열이 발생하도록 높은 광안정성의 유기 쿼터릴렌 NIR 염료 IR788이 캡슐화된 나노입자에 대해 보고한다. 또한, 저온에서의 구조적 안정성을 보장하기 위해서 마이셀 중심부에 반상호침투 네트워크를 형성한다. 그 결과, 일반적으로 광열치료에 주로 사용되는 유기 NIR 염료인 인도시아닌 그린 (Indocyanine Green)과 비교하여 더 높은 광열 특성을 나타냈다

URI: https://repository.pknu.ac.kr:8443/handle/2021.oak/23745
http://pknu.dcollection.net/common/orgView/200000283012

Table Of Contents: 1. Introduction 1
1.1. Research Overview 1
1.2. Literature Review 4
1.2.1. Indocyanine Green and Rylene Dyes 4
1.2.2. Polymeric Micelles and Semi-Interpenetrating Network (sIPN) 7
1.2.3. Heat Conversion Efficiency of Photothermal Material 10
2. IR788 sIPN Formation and Stability Studies 14
2.1. Methodology 14
2.1.1. Materials 14
2.1.2. Instruments 15
2.2. Experimental 15
2.2.1. Preparation of IR788 sIPN 15
2.2.2. CMT Test 17
2.2.3. Photostability Evaluation of IR788 sIPN 17
2.3. Results and Discussion 18
2.3.1. IR788 sIPN Formation 18
2.3.2. Photostability Evaluation of IR788 sIPN 21
3. Photothermal Analysis of Polymeric Nanoparticles 25
3.1. Methodology 25
3.1.1. Materials 25
3.1.2. Instruments 26
3.2. Experimental 26
3.2.1. Photothermal Effect on Various Conditions 26
3.2.1.1. Solution Concentration Variation 26
3.2.1.2. Laser Power Variation 27
3.2.1.3. Irradiation Temperature Variation 28
3.2.2. Photothermal Conversion Eficiency and Stability of IR788 sIPN 28
3.3. Results and Discussion 29
3.3.1. Concentration-Dependent Hyperthermia 29
3.3.2. Laser Power-Dependent Hyperthermia 32
3.3.3. Irradiation Temperature-Dependent Hyperthermia 34
3.3.4. Photothermal Performance of IR788 sIPN 38
4. Conclusions 41
5. References 42

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