비소 노출에 따른 강도다리의 생체축적, 혈액학적, 항산화 및 면역 반응의 변화

Abstract

In order to confirm bioaccumulation and changes in hematological, antioxidant and immune responses of starry flounder following exposure to arsenic, feed prepared at levels of 0, 5, 10, 20, 40 and 80 mg / kg of arsenic for 4 weeks were exposed to starry flounder, Platichthys stellatus (length 20.9 ± 1.6cm, weight 152.5 ± 13.7g). bioaccumulation following arsenic exposure showed high accumulation in the order of intestine, liver, and gills, and significantly increased above 20 mg / kg concentration. growth rate and liver weight index showed a significant decrease at concentrations above 40 mg / kg. hematological markers of RBC count, hemoglobin, and hematocrit were significantly decreased at high concentrations of 80 mg / kg. plasma minerals calcium and magnesium did not show significant changes. plasma organic component glucose showed a significant increase, but total protein did not show a significant change. Plasma enzymes, GOT and GPT, showed significant increase at 80 mg / kg concentration at 4 weeks. antioxidant response to arsenic exposure was analyzed using gills and liver, and SOD and CAT were observed. both SOD and CAT showed significant increase in gill and liver tissue. in experiments to observe the immune response, plasma lysozyme activity showed a significant decrease above 40 mg / kg concentration. in the acetylcholinesterase activity test, brain, intestine, and liver were used and there was a significant increase. In conclusion, exposure to arsenic induced bioaccumulation and altered hematological properties, antioxidant and immune responses.