타이타늄의 전기화학적 나노패턴 형성 표면의 생체적합성

Abstract

Titanium and titanium alloys are widely used as biomaterials for dental implants, orthopedic implants, stents, etc. due to their excellent biocompatibility and mechanical properties such as corrosion resistance, strength and toughness. However, Titanium has a bioinert property, so various surface treatments have been performed to improve biocompatibility. The adhesion, spreading, growth and differentiation of mesenchymal stem cells are influenced by the diameter of TiO2 tubes made of anodization, and it is reported that integrin clustering/focal contact formation and cellular activity are strongly improved at diameters of 15 nm to 30 nm. This means that cell growth and apoptosis can be controlled by surface treatment alone without chemical treatment. However, TiO2 tube made of anodization have poor mechanical strength and are subject to surface contamination during anodization. So we developed a surface called ‘ENF’ which is obtained by removing TiO2 tube by chemical etching. The ENF surface treatment method introduced in this thesis is a surface treatment method using anodization that does not harmful to human body because it does not use an acid solution, and it have metallic surface with TiO2 tube layer removed with high mechanical strength, and it can be expected to form excellent biocompatibility by forming surface roughness of multi scale with both 10 nm nanopores and 100 nm dimple on titanium surfaces.