Synthesis of magnetic hydroxyapatite and magnetic core-shell nanoparticles for biomedical applications

Abstract

We have prepared a core-shell magnetic@silica-based hydroxyapatite, Fe3O4@SiO2@HAp composite materials for pH-responsive drug delivery applications. A hydrophilic drug, captopril (Cap) and hydrophobic drug, ibuprofen (Ibu) was chosen as a model hydrophilic and hydrophobic drugs. The drugs was encapsulated into the Fe3O4@SiO2@HAp composite via electrostatic interactions with existed amine and carboxylic acid groups during calcium phosphate (CaP) shell formation.. We have tested the release behavior of Cap and Ibu drugs under different pH conditions such as neutral pH (pH 7.4) and acidic pH (pH 5.0), respectively. The study result reveal that the synthesized Fe3O4@SiO2@HAp composite is suitable for release of both water soluble and water non-soluble drugs based on a pH-responsive controlled manner. The study on the straightforward fabrication of polyethylenimine-doxorubicin (PEI-DOX) Fe3O4@SiO2@TiO2 core-shell nanoparticles for pH stimuli-responsive drug delivery applications. The fabricated nanocarrier system consists of a magnetic iron core (Fe3O4), silica shell (SiO2), titania second shell (TiO2) and the final PEI cationic polymer shell with an drug DOX for pH-responsive drug delivery applications. We have observed the release behavior of the drug DOX under different pH conditions. The study results reinforce that the synthesized PEI-DOX Fe3O4@SiO2@TiO2 core-shell nanoparticles are suitable for pH stimuli responsive drug release system. In addition to their excellent drug release performance, the system demonstrates good efficacy against the MDA-MB-231 breast cancer cells. Therefore, the fabricated Fe3O4@SiO2@TiO2 core-shell nanoparticles act as a good nanodrug carrier for loading and releasing DOX.