High-intensity focused ultrasound power amplifier design for breast tumor treatment integrated with highly efficient photo-acoustic and fluorescent imaging

Abstract

High intensity focused ultrasound (HIFU) has been used widely for solid tumor treatment as an efficiently non-invasive technique. Using HIFU, we can create an ultrasound (US) beam as a high-frequency pressure wave propagates through soft tissue. The US beam will focus at a tiny target area, and based on the energy power, the temperature increases and within a few seconds the coagulative necrosis and protein denaturation occur. The energy of the sound wave produced from the transducer depends on the capacity of the power amplifier circuit. In this thesis, we reported a low-cost electrical design to replace the expensive system normally used like RF Amplifier for driving the HIFU transducer. For verifying the feasibility of this design in research application, we prepared the ex-vivo and in vivo experiment. In this setup, we also included the chitosan–polypyrrole nanoparticle as a material for the treatment process. In addition, the photo-acoustic and fluorescent imaging systems are used too for ensuring the effect of the therapeutic modality.