홍합과 한약재 혼합 추출물의 알코올 분해 효소 활성에 대한 상승 효과

Abstract

Hangover refers to an unpleasant headache, nausea, and dizziness that people feel after drinking. This is caused by acetaldehyde decomposed from alcohol. Alcohol dehydrogenase (ADH), acetaldehyde dehydrogenase (ALDH) act to decompose acetaldehyde. This study was aimed to evaluate the effect of mixing mussels and herbal medicines on alcohol metabolizing enzymatic and the synergic effect. And blue mussel or herbal medicines had functional ingredient respectively. Samples were extracted with hot water, and the activity of ADH and ALDH were measured and compared. Samples were A (blue mussel), B (arrowroot), C (dried orange peel), D (magnolia), E (quince), F (lonicer aflower), G (blue mussel + arrowroot), H (blue mussel + dried orange peel), I (blue mussel + magnolia), J (blue mussel + quince) and K (blue mussel + lonicer aflower). Extract B showed the highest effect for the activities of ADH (710±4.6%) and ALDH (1716.6±7.5%). And the addition of blue mussel and extract G did provide a synergy effect. And extract C had lower ADH and ALDH activities than other extracts, but exhibited a synergistic effect. Although extract D showed high ADH and ALDH activity, it did not show synergistic effect. As a result, extract B had high value and synergy effect. Arrowroot with blue mussel is expected to help reliving hangover.