초임계 이산화탄소를 이용한 cyclodextrin 유도체의 미립화 및 약물 담지

Abstract

In general, the method of manufacturing fine particles through polymer synthesis is a method of polymerizing by dissolving a low-molecular monomer in a solvent, and the solvent is determined according to the monomer, and various additives are used accordingly. In order to obtain pure products, it is essential to remove impurities such as initiators and additives. In this process, it affects the purity and yield of the product, and it takes a long time to obtain the product. On the other hand, the supercritical fluid used as an environmentally friendly solvent has a small effect on the purity and yield of the product and can be easily removed after being used as a solvent. As described above, the method for producing fine particles using a supercritical fluid can quickly and easily obtain a product. Various fluids are used in the technology of manufacturing nanoparticles using supercritical fluids, and the fluids are classified into three types: solvent, antisolvent, or assist. In this study, rapid expansion of a supercritical solutions (RESS), which is a method of manufacturing fine particles by rapidly expanding the material dissolved was used. In this study, the fine particles of PAc-β-CD and MOL-supported PAc-β-CD particles are sized according to concentration, temperature, nozzle ID (inner diameter), nozzle length, and spray distance, respectively, using a RESS process using a supercritical fluid. How it changed was confirmed. In the case of PAc-β-CD carrying the drug, additional drug release time was confirmed. In addition, changes in the particle size of octakis (6-O-perfluorobutanoyl)-γ-cyclodextrin (F-γ-CD) obtained through synthesis of γ-CD and HeptaFluorobutyric acid were also investigated.