색소 병변 치료 및 피부 재생을 위한 피코초 엔디야그레이저 기반 회절 마이크로 렌즈 어레이(DLA) 개발 연구

Abstract

Picosecond Nd:YAG laser using diffractive optical element (DOE) and micro-lens array (MLA) has widely been used in dermatology for treatment of pigmented lesions and skin rejuvenation. This study designed and developed a new optical element of diffractive micro-lens array (DLA) by combing the features of DOE and MLA in order to achieve uniform and selective laser treatment. Both optical simulation and beam profile measurement demonstrated that DLA created a square macro-beam consisting of multiple micro-beams in a uniform distribution. Histological analysis confirmed that the DLA-assisted laser treatment generated micro-injuries at various skin depths from epidermal layer to deep dermal layer (up to 1200 μm) by adjusting the focal depths while DOE showed shallow penetration depths and MLA created non-uniform micro-injury zones. The DLA-assisted picosecond Nd:YAG laser irradiation can provide a potential benefit for pigment removal and skin rejuvenation via uniform and selective laser treatment.