강도다리, Platichthys stellatus의 항산화, 면역 반응 및 HSP70에 미치는 Bisphenol A의 독성영향

Abstract

Bisphenol A (BPA) is a representative endocrine disruptor used in various industries and is known to destroy the endocrine system of fish and cause developmental and metabolic disorders. This study was conducted to investigate the effect of BPA on growth performance, hematological parameters, antioxidant, stress and immune response in starry flounder, P latichthys stellatus (mean weight, 38.6 ± 6.8 g; mean length, 14.8 ± 0.6 cm). Starry flounder, P latichthys stellatus were exposed for 20 days with differenok236955t levels of Bispenol A ( 0, 100, 200, 400 and 800 ug/L). Growth performances such as body weight gain (BWG), specific growth rate (SGR) and hepatosomatic index (HSI) were significantly decreased by BPA exposure. Hematological parameters such as red blood cell (RBC) count and hemoglobin were also significantly decreased. In plasma inorganic components, calcium and magnesium were significantly decreased by BPA exposure. In enzyme plasma components, glutamic oxalate transaminase (GOT) and glutamic pyruvate transaminase (GPT) were significantly increased. The superoxide dismutase activity (SOD), catalase activity (CAT) were significantly decreased compared with control group. Immune response such as lysozyme activity and IgM were also significantly decreased. Stress response such as cortisol and heat shock protein 70 (HSP70) were significantly increased by BPA exposure.