Synthesis of Polymers, Polymeric Nanoparticles, and Molecularly Encapsulated Organic Compounds Using Supercritical Carbon Dioxide
- Alternative Title
- 초임계이산화탄소를 이용한 고분자, 고분자 나노입자 및 분자가 캡슐화된 유기 화합물의 제조
- Abstract
- Supercritical carbon dioxide (scCO₂) was used as a solvent for different type of polymerizations, such as oxidative polymerization to prepare functionalized semi-conducting polythiophenes, ring-opening polymerization of L-lactide to prepare biodegradable polymers, and also the free-radical dispersion polymerizations of vinyl monomer, methyl methacrylate (MMA). Furthermore, semi-conducting polymeric nanoparticles were prepared by rapid expansion of supercritical solutions (RESS and RESOLV) method. Additionally, scCO₂ was also used a solvent for the molecular encapsulation of hydrophilic drugs into functionalized cyclodextrins for their potential use in controlled drug delivery applications.
초 임계이산화탄소 (scCO₂)는 치환된 반전도성 폴리티오펜을 제조하기 위한 산화중합, 생 분해성 고분자를 제조하기 위한 L-락타이드의 고리 열림 중합, 또는 메틸 메타크릴레이트 (MMA)와 같은 비닐계 단량체의 자유 라디칼 분산 중합과 같은 다른 종류의 중합 용매로 사용된다. 그리고 반전도성 고분자 나노입자는 초 임계 유체의 빠른 확산(PRESS와 RESOLV)에 의해 제조된다. 추가적으로 초 임계이산화탄소는 조절된 약물 전달 응용분야에서 사용하기 위하여 치환된 사이클로 덱스트린으로 수용성 약물을 분자 캡슐로 만들기 위한 용매로도 이용할 수 있다.
- Issued Date
- 2007
- Awarded Date
- 2007. 8
- Type
- Dissertation
- Keyword
- Supercritical Carbon Dioxide Polymeric Nanoparticles Conducting Polymers Biodegradable Polymers RESS & RESOLV Drug Derivery Cyclodextrin
- Publisher
- 부경대학교 일반대학원
- Alternative Author(s)
- 가나파티 수반 훌라티
- Affiliation
- 부경대학교 일반대학원
- Department
- 대학원 이미지시스템공학과
- Advisor
- 임권택
- Table Of Contents
- Chapter 1 General Introduction = 1
1.1. Supercritical fluids = 2
1.2. Polymer synthesis using scCO₂ = 5
1.3. Engineering polymeric particles using scCO₂ = 9
1.4. CO₂-assisted encapsulation and impregnation of organic compounds = 12
1.5. Aim and outline of this thesis = 13
1.6. References = 16
Chapter 2 Synthesis and Properties of CO₂-Soluble Fluoroalkyl Ester-Functionalized Plythiophenes in Supercritical Carbon Dioxide = 20
2.1. Introduction = 21
2.2. Experimental section = 23
2.2.1. Materials = 23
2.2.2. Characterization = 23
2.2.3. Experimental setup for polymerization in CO₂ = 24
2.2.4. Polymer-scCO₂ phase-behavior measurements = 24
2.2.5. Synthesis of monomers = 25
2.2.6. Synthesis of 2-(3-thienyl)methyl perfluorobutyrate (FTE1) = 26
2.2.7. Synthesis of 2-(3-thienyl)methyl pentadecafluorooctonate (FTE2) = 27
2.2.8. Synthesis of 2-(3-thienyl ethylperfluorobutyrate) (FTE3) = 28
2.2.9. Synthesis of 2-(3-thienyl) acetyl 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-octanoate (SFTE) = 28
2.2.10. Synthesis of polymers: polymerization in chloroform = 28
2.2.11. Polymerization in scCO₂ = 29
2.3. Results and discussion = 29
2.3.1. Characterization of polymers = 29
2.3.2. Solubility of polymers in scCO₂ = 37
2.4. Conclusions = 41
2.5. References = 42
Chapter- 3 Ring-Opening Polymerization of_(L)-Lactide in scCO₂ Using PDMS Based Stabilizers = 45
3.1. Introduction = 46
3.2. Experimental section = 48
3.2.1. Materials = 48
3.2.2. Synthesis of PDMS based stabilizers = 50
3.2.3. Stabilizer- scCO₂ phase behavior measurements = 50
3.2.4. Experimental set up and procedure for ROP of_(L)-lactide in CO₂ = 51
3.2.5. Characterization = 52
3.3. Results and discussion = 52
3.3.1. Solubility of stabilizers in scCO₂ = 52
3.3.2. Ring-opening suspension polymerization of_(L)-lactide in scCO₂ = 53
3.4. Conclusions = 59
3.5. References = 59
Chapter 4 Polymerization of Methyl Methacrylate in scCO₂ with PDMS based stabilizers: A study on the effect of stabilizer anchor groups = 62
4.1. Introduction = 63
4.2. Experimental section = 64
4.2.1. Materials and methods = 64
4.3. Result and discussion = 64
4.4. Conclusions = 68
4.5. References = 68
Chapter 5 Preparation of Polymeric Particles by Supercritical Fluid Process = 70
5.1. Introduction = 71
5.2. Results and Discussion = 72
5.3 Conclusions = 77
5.4. Experimental Section = 77
5.4.1. Materials = 77
5.4.2. Synthesis of poly[2-(3-thienyl)acetyl 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-octanoate](PSFTE) = 78
5.4.3. Characterization = 78
5.4.4. Solubility of PSFTE in CO₂ = 79
5.5. References = 79
Chapter 6 Preparation of Fluorinated Ester Functionalized Polythiophene Nanoparticles by RESOLV Process = 81
6.1. Introduction = 82
6.2. Experimental Details = 83
6.3. Results and Discussion = 84
6.4. Conclusions = 90
6.5 References = 91
Chapter 7 Supercritical CO₂-Assisted Molecular Encapsulation of Water-soluble Drug into Peracetylated-β-Cyclodextrin for Controlled Delivery Applications = 93
7.1. Introduction = 94
7.2. Experimental = 94
7.3. Results and Discussion = 95
7.4. Conclusions = 100
7.5. References = 100
Chapter 8 Supercritical Carbon Dioxide Assisted Impregnation of Molsidomine into Poly(_(DL)-Lactide-co-glycolide) for Sustained Release Applications = 102
8.1. Introduction = 103
8.2. Experimental Section = 104
8.3. Results and Discussion = 104
8.4. Conclusions = 108
8.5. References = 109
Summary = 110
Acknowledgements = 114
Ⅰ. Publications = 116
Ⅱ. Patents = 119
- Degree
- Doctor
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