에어로졸 데포지션에 의한 수산화 아파타이트 코팅층에 불소 첨가에 따른 생체 특성 효과에 관한 연구

Abstract

Dense and well-adherent fluoridated hydroxyapatite [Ca10(PO4)6(OH)2-xFx, where x=0, 0.5, 1.0, 1.5, 2.0 FHA] coatings were deposited on commercially available pure titanium by aerosol deposition using FHA powders. FHA powders with different compositions were synthesized by solid-state reactions of hydroxyapatite(HA) and fluorapatite(FA) powder s at various ratios .X-ray diffraction and Fourier transform infrared spectroscopy results showed that fluoridations were successfully incorporated into the HA lattice for both the FHA powders and the FHA coatings. Scanning electron microscopy analysis revealed dense microstructures and good substrate adhesion of the coatings with high adhesion strengths of more than 33.1MPa. The dissolution behavior in a Tris-buffered saline solution indicated that the dissolution rate of the FHA coatings decreased as a result of increasing the fluorine content in the coatings. In addition, in vitro cellular tests, including cell attachment, proliferation, and alkaline phosphate activity of MC3T3-E1 preosteoblast cells grown on the coatings, demonstrated that an FHA coating with a moderate degree of F-substitution, x=1.0, had a stronger stimulating effect on cellproliferation and differentiation. These results suggested that there exists an optimum fluorine content level in the FHA coatings for the best long-term stability and cellular responses.