Synthesis of Core-crosslinked Block Copolymer Micelles via RAFT Polymerization
- Abstract
- The limited stability of micelles against dissociation was overcome by the covalent crosslinking of micellar cores. The amphiphilic block copolymers synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, poly(ethylene oxide)-b-polystyrene (PEO-b-PS), poly(acrylic acid)-b-polystyrene (PAA-b-PS), still carry the trithiocarbonate group. Further chain extension can be carried out by restarting the polymerization in the presence of a new monomer. Therefore, this process was utilized to crosslink the micelles following the self-assembly of block copolymer in selective solvent. The self-assembly of block copolymers and the crosslinking reaction of micellar cores by
RAFT polymerization using crosslinker were attempted to occur in one pot.
- Issued Date
- 2011
- Awarded Date
- 2011. 8
- Type
- Dissertation
- Publisher
- 부경대학교 대학원
- Department
- 대학원 이미지시스템공학과
- Advisor
- 임권택
- Table Of Contents
- Chapter 1.Generation Introduction 1
1.1. Introduction to block copolymer 1
1.2. Block copolymer micelles 2
1.2.1. Micellization 2
1.2.2. Applications
1.3. Crosslinked micelles 4
1.4. Reversible addition-fragmentation chain transfer polymerization 6
1.4.1. Synthesis of block copolymer 6
1.4.2. Reversible addition fragment chain transfer (RAFT) polymerization 7
1.5. Aim and outline of the thesis 9
1.6. References 10
Chapter 2. Facile Synthesis of Core-Surface Crosslinked Nanoparticles by Interblock RAFT Polymerization 13
2.1. Introduction 14
2.2. Experimental section 15
2.2.1. Materials 15
2.2.2. Synthesis of 3-(benzylthiocarbonothioylthio) propanoic acid 16
2.2.3. Synthesis of 3-benzylsulfanylthiocarbo propionyl chloride 16
2.2.4. Synthesis of PEO-based macro-CTA (PEO-RAFT agent) 17
2.2.5. Synthesis of PEO- b-PS copolymer 17
2.2.6. Synthesis of interblock crosslinked (PEO-b-PDVB-b-PS) nanoparticles 18
2.2.7. Characterization 18
2.3. Results and discussion 19
2.4. Conclusions 25
2.5. References 26
Chapter 3. Facile Synthesis of Core-crosslinked Micelles Containing Poly (acrylic acid) Corona via RAFT Polymerization 28
3.1. Introduction 29
3.2. Experimental section 31
3.2.1. Materials 31
3.2.2. Synthesis of 3-(benzylthiocarbonothioylthio) propanoic acid 31
3.2.3. Synthesis of the poly(acrylic acid) (PAA) trithiocarbonate macro-RAFT agent 32
3.2.4. Synthesis of PAA-b-PS copolymer 32
3.2.5. Synthesis of inter-block crosslinked nanoparticles 33
3.2.6. Characterization 33
3.3. Results and discussion 34
3.3.1. Synthesis of PAA-b-PS 34
3.3.2. Synthesis of core-crosslinked micelles in ethanol 37
3.3.3. Preparation of core-crosslinked micelles with different ratios of the crosslinker to the block copolymer 43
3.4. Conclusions 47
3.5. References 48
Acknowledgements 52
- Degree
- Master
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