자기 온열치료 시스템의 열 발생 효율에 관한 연구

Abstract

We successfully demonstrated heat generation efficiency of the magnetic hyperthermia system to find optimal condition using gelatin tissue phantom. Magnetic hyperthermia induction heat generation of the magnetic gelatin tissue phantom with different concentration of Fe3O4 iron oxide was conducted at a frequency of 145㎑ with alternating current magnetic field intensity from 145 to 218Gauss. It was observed that the maximum temperature achieved in the magnetic gelatin tissue phantom increased with the concentration of Fe3O4 iron oxide and alternating magnetic field intensity. The efficient configuration of magnetic hyperthermia system was found for 1.5wt.% Fe3O4 in gelatin tissue phantom with applied AC magnetic field intensity achieve increased above 42℃ using optimized experimental condition 215G-1.5wt.% in magnetic hyperthermia treatment. Results were discussed with respect to further optimization of therapeutic technique for biomedical application with modified functional nanoparticles.